Vaccine effectiveness of PCV13 in a 3 + 1 vaccination schedule. Issue 18 (19th April 2016)

• Record Type: Journal Article
• Authors: Weinberger, Raphael; van der Linden, Mark; Imöhl, Matthias; von Kries, Rüdiger
• Is Part Of: Vaccine. Volume 34:Issue 18(2016)
• Page Start: 2062
• Page End: 2065
• Publication Date: 2016-04-19
• Subjects: Invasive pneumococcal disease -- Vaccine effectiveness PCV13 -- 3 + 1 Vaccination schedule -- Pneumococcal conjugate vaccination -- Germany; Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2016.02.043
• Languages: English
• ISSNs: 0264-410X

Abstract

Abstract: Objective: To assess the vaccine effectiveness (VE) of PCV13 for invasive pneumococcal disease (IPD) regarding the extra six serotypes with a 3 + 1 schedule in Germany. Methods: Active surveillance for IPD in children <16 years eligible for PCV13 vaccination. We used the Broome method and logistic regression to estimate VE. Results: Data on 164/304 reported IPD cases were informative and met the inclusion criteria. VE for the extra six serotypes was 88% [95% confidence interval (CI): 73; 95] and 83% [56; 94] for at least one and for at least two doses respectively. VE for the complete 3 + 1 vaccination schedule was not conclusive because of a wide 95% CI. For serotype 3 VE appeared to be zero with an even wider 95% CI. Conclusion: PCV13 VE against the extra six serotypes with the 3 + 1 schedule in Germany was only marginally higher compared to previously published data for the 2 + 1 schedule.