Tissue morphodynamics: Translating planar polarity cues into polarized cell behaviors. (July 2016)

• Record Type: Journal Article
• Authors: Devenport, Danelle
• Is Part Of: Seminars in cell & developmental biology. Volume 55(2016)
• Page Start: 99
• Page End: 110
• Publication Date: 2016-07
• Subjects: Planar polarity -- Cell polarity -- Cilia -- Asymmetric cell division -- Wing hairs -- Stereocilia -- Convergent extension -- Hair follicles -- Directional signaling -- Planar cell polarity; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2016.03.012
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: The ability of cells to collectively orient and align their behaviors is essential in multicellular organisms for unidirectional cilia beating, collective cell movements, oriented cell divisions, and asymmetric cell fate specification. The planar cell polarity pathway coordinates a vast and diverse array of collective cell behaviors by intersecting with downstream pathways that regulate cytoskeletal dynamics and intercellular signaling. How the planar polarity pathway translates directional cues to produce polarized cell behaviors is the focus of this review.