Antithrombotic activities of fucosylated chondroitin sulfates and their depolymerized fragments from two sea cucumbers. (5th November 2016)

• Record Type: Journal Article
• Authors: Liu, Xiaoxiao; Hao, Jiejie; Shan, Xindi; Zhang, Xiao; Zhao, Xiaoliang; Li, Qinying; Wang, Xiaojiang; Cai, Chao; Li, Guoyun; Yu, Guangli
• Is Part Of: Carbohydrate polymers. Volume 152(2016)
• Page Start: 343
• Page End: 350
• Publication Date: 2016-11-05
• Subjects: Fucosylated chondroitin sulfate -- Sulfation pattern -- Molecular weight -- Antithrombotic -- Anticoagulant; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2016.06.106
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: FCSs structures from two sea cucumbers were characterized. Anticoagulant and anti-thrombotic activity were compared in vitro and in vivo . FCSs had similar activity with different sulfation patterns. Sulfation patterns might not affect anti-thrombotic activity as much as molecular weight. Abstract: Fucosylated chondroitin sulfate (FCS), a glycosaminoglycan extracted from the body wall of sea cucumber, is a promising antithrombotic agent. The chemical structures of FCS c isolated from sea cucumber Cucumaria frondosa and its depolymerized fragment (dFCSc) were characterized for the first time. Additionally, anticoagulant and antithrombotic activities were evaluated in vitro and in vivo . The results demonstrated that dFCS c exhibited better antithrombotic-hemorrhagic ratio than native FCS c on the electrical induced arterial thrombosis model in rats. Compared to FCS t obtained from Thelenota ananas, FCS c possessed different sulfation patterns but similar antithrombotic effects. Therefore, sulfation pattern of FCS might not affect anticoagulation and antithrombosis as much as molecular weight may. Our results proposed a new point of view to understand the structure-activity relationship of FCS as alternative agents.