Repurposing strategies for tropical disease drug discovery. Issue 11 (1st June 2016)

• Record Type: Journal Article
• Authors: Klug, Dana M.; Gelb, Michael H.; Pollastri, Michael P.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 11(2016)
• Page Start: 2569
• Page End: 2576
• Publication Date: 2016-06-01
• Subjects: Drug repurposing -- Target repurposing -- Lead repurposing -- Target class repurposing -- Neglected tropical disease -- Tropical disease -- Piggy-back drug discovery -- Drug repositioning; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.03.103
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Neglected tropical diseases (NTDs) and other diseases of the developing world, such as malaria, attract research investments that are disproportionately low compared to their impact on human health worldwide. Therefore, pragmatic methods for launching new drug discovery programs have emerged that repurpose existing chemical matter as new drugs or new starting points for optimization. In this Digest we describe applications of different repurposing approaches for NTDs, and provide a means by which these approaches may be differentiated from each other. These include drug repurposing, target repurposing, target class repurposing, and lead repurposing.