Dropout rates in couples undergoing in vitro fertilization and intrauterine insemination. (October 2016)

• Record Type: Journal Article
• Authors: Bensdorp, Alexandra J.; Tjon-Kon-Fat, Raissa; Verhoeve, Harold; Koks, Carolien; Hompes, Peter; Hoek, Annemieke; de Bruin, Jan Peter; Cohlen, Ben; Hoozemans, Diederik; Broekmans, Frank; van Bomme, Peter; Smeenk, Jesper; Mol, Ben W.J.; van der Veen, Fulco; van Wely, Madelon
• Is Part Of: European journal of obstetrics, gynecology, and reproductive biology. Volume 205(2016:Oct.)
• Page Start: 66
• Page End: 71
• Publication Date: 2016-10
• Subjects: Dropout rates -- Intrauterine insemination -- In vitro fertilization -- Modified natural cycle -- Single embryo transfer; Obstetrics -- Periodicals; Gynecology -- Periodicals; Reproductive health -- Periodicals; Gynecology -- Periodicals; Obstetrics -- Periodicals; Reproduction -- Periodicals; Obstétrique -- Périodiques; Gynécologie -- Périodiques; Reproduction -- Périodiques; Verloskunde; Gynaecologie; Voortplanting (biologie); Gynecology; Obstetrics; Reproduction; Electronic journals; Periodicals; Electronic journals; 618.05
• DOI: 10.1016/j.ejogrb.2016.08.018
• Languages: English
• ISSNs: 0301-2115

Abstract

Abstract: Objective: To compare dropout rates in couples undergoing conventional in vitro fertilization with single embryo transfer (IVF-SET), in vitro fertilization in a modified natural cycle (IVF-MNC) or intrauterine insemination with ovarian stimulation (IUI-OS). Study design: Secondary analysis of a multicentre randomized controlled trial between January 2009 and February 2012. 602 couples with unexplained or mild male subfertility, allocated to IVF-SET ( N = 201), IVF-MNC ( N = 194) and IUI-OS ( N = 207). Main outcome measures: Dropouts, defined as couples who discontinued their allocated three cycles of IVF-SET, six cycles of IVF-MNC or IUI-OS, without having achieved a pregnancy. We classified dropouts as "following medical advice" or "patient initiated". Result(s): Thirty couples (15%) allocated to IVF-SET dropped out and 45 couples (23%) allocated to IVF-MNC, compared to 26 couples (13%) allocated to IUI-OS; relative risk (RR) 1.2 (95%CI; 0.73–1.9) for IVF-SET and 1.9 (95%CI; 1.2–2.9) for IVF-MNC, both compared to IUI-OS. Nine couples (4.5%) allocated to IVF-SET, 14 (7.2%) allocated to IVF-MNC and 14 (6.8%) allocated to IUI-OS dropped out following medical advice; RR of 0.51 (95%CI; 0.21–1.2) for IVF-SET and 0.84 (95%CI; 0.39–1.80) for IVF-MNC, both versus IUI-OS. Twenty-one couples (10%) allocated to IVF-SET were patient initiated dropouts, as were 31 (16%) allocated to IVF-MNC and 12 (5.8%) allocated to IUI-COS; RR 1.8 (95%CI; 0.91–3.6) for IVF-SET and 2.8 (95%CI; 1.5–5.2) for IVF-MNC both versus IUI-OS. Conclusion(s): IVF-SET and IUI-OS result in comparable drop-out rates, while drop-out rates after IVF-MNC are almost twice as high, mainly driven by patient preferences.