Molecularly imprinted polymers by reversible chain transfer catalysed polymerization. (5th November 2015)

• Record Type: Journal Article
• Authors: Bompart, Marc; Goto, Atsushi; Wattraint, Olivier; Sarazin, Catherine; Tsujii, Yoshinobu; Gonzato, Carlo; Haupt, Karsten
• Is Part Of: Polymer. Volume 78(2015)
• Page Start: 31
• Page End: 36
• Publication Date: 2015-11-05
• Subjects: Molecularly imprinted polymer -- Reversible chain-transfer catalysed polymerization -- Living radical polymerization; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; 547.7
• DOI: 10.1016/j.polymer.2015.09.060
• Languages: English
• ISSNs: 0032-3861

Abstract

Abstract: Molecularly imprinted polymers (MIPs) are tailor-made biomimetic receptors obtained by polymerization in the presence of molecular templates. They contain binding sites for target molecules with affinities and specificities on a par with those of antibodies, hormone receptors or enzymes. Mainly synthesized via radical polymerization of vinyl monomers, MIPs have also recently taken advantage of the introduction of modern methods of controlled/living radical polymerization (CRPs). In this paper, we report for the first time the use for MIP synthesis of a recently developed CRP method based on an iodide-transfer polymerization with a reversible activation mechanism, referred to as Reversible chain-Transfer Catalysed Polymerization (RTCP). Using S-propranolol as model template, we show that this technique is a convenient method for the synthesis of MIPs, both in the format of bulk polymers and nanoparticles, yielding polymers with reactive chain ends for an easy surface functionalization. Graphical abstract: Highlights: We report the first synthesis of imprinted polymers (MIPs) by RTCP. Bulk monoliths and spherical particles were the tested formats. RTCP performs similarly to FRP in terms of binding properties. RTCP allows for an easy surface functionalization.