Advanced research technology for discovery of new effective compounds from Chinese herbal medicine and their molecular targets. (September 2016)

• Record Type: Journal Article
• Authors: Wong, Vincent Kam-Wai; Law, Betty Yuen-Kwan; Yao, Xiao-Jun; Chen, Xi; Xu, Su Wei; Liu, Liang; Leung, Elaine Lai-Han
• Is Part Of: Pharmacological research. Volume 111(2016:Sep.)
• Page Start: 546
• Page End: 555
• Publication Date: 2016-09
• Subjects: CHM Chinese herbal medicine -- EGCG epigallocatechin 3-gallate -- TAIII imosaponin A-III -- DHRh-123 dihydrorhodamine-123 -- DARTS drug affinity responsive target stability -- TEMtfLC3 tandem fluorescent-tagged microtubule associated protein 1 light chain 3 -- mRFP momomeric red fluorencent protein -- GFP green fluorescent protein -- LC3 protein 1 light chain 3 -- AKT protein kinase B -- Atg 5 autophagy protein 5 -- mTOR mechanistic target of rapamycin -- TEM transmission electron microscopy -- LOX-1 15-lipoxygenase-1 -- PPAR proliferator-activated receptor -- IDO indoleamine 2, 3-dioxygenase -- BLI bioluminescent imaging -- Luc luciferase -- HIF-1 hypoxia-inducible factors 1 -- TKI styrosine kinase inhibitors -- PTM post-translational modification -- ROS reactive oxygen species; Chinese herbal medicine -- New phytochemicals -- Mechanism -- Omics -- Biotechnology -- Computational technology; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2016.07.022
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Traditional biotechnology has been utilized by human civilization for long in wide aspects of our daily life, such as wine and vinegar production, which can generate new phytochemicals from natural products using micro-organism. Today, with advanced biotechnology, diverse applications and advantages have been exhibited not only in bringing benefits to increase the diversity and composition of herbal phytochemicals, but also helping to elucidate the treatment mechanism and accelerate new drug discovery from Chinese herbal medicine (CHM). Applications on phytochemical biotechnologies and microbial biotechnologies have been promoted to enhance phytochemical diversity. Cell labeling and imaging technology and ⿿omics technology have been utilized to elucidate CHM treatment mechanism. Application of computational methods, such as chemoinformatics and bioinformatics provide new insights on direct target of CHM. Overall, these technologies provide efficient ways to overcome the bottleneck of CHM, such as helping to increase the phytochemical diversity, match their molecular targets and elucidate the treatment mechanism. Potentially, new oriented herbal phytochemicals and their corresponding drug targets can be identified. In perspective, tighter integration of multi-disciplinary biotechnology and computational technology will be the cornerstone to accelerate new arena formation, advancement and revolution in the fields of CHM and world pharmaceutical industry.