Pilot Study Comparing 2 Oral Rehydration Solutions in Patients With Short Bowel Syndrome Receiving Home Parenteral Nutrition: A Prospective Double-Blind Randomized Controlled Trial. (December 2017)

• Record Type: Journal Article
• Authors: Hurt, Ryan T.; Vallumsetla, Nishanth; Edakkanambeth Varayil, Jithinraj; Bonnes, Sara L.; Nanda, Sanjeev; Nadeau, Joseph; Mundi, Manpreet S.
• Is Part Of: Nutrition in clinical practice. Volume 32:Number 6(2017:Dec.)
• Page Start: 814
• Page End: 819
• Publication Date: 2017-12
• Subjects: parenteral nutrition -- short bowel syndrome -- fluid therapy -- rehydration solutions -- dehydration -- water-electrolyte balance; Nutrition -- Periodicals; Diet therapy -- Periodicals; Artificial feeding -- Periodicals; 615.854
• DOI: 10.1177/0884533617714975
• Languages: English
• ISSNs: 0884-5336

Abstract

Background: Short bowel syndrome (SBS) is a common indication for home parenteral nutrition (HPN). Oral rehydration solutions (ORSs) have the ability to supplement or reduce HPN dependence. However, ORSs have suffered from poor taste profiles, making long-term consumption and compliance unlikely. The goal of the current study was to assess the taste and compliance of 2 ORSs among patients with SBS requiring HPN. Methods: All participants with SBS receiving HPN with anticipated duration >3 months were offered enrollment: 31 participants met inclusion criteria; 3 declined enrollment; and 28 were randomized to receive a modified World Health Organization ORS (group A) or a commercially available ORS (DripDrop; group B). Results: Six participants dropped out shortly after randomization (3 in each group) due to poor taste or intolerance. An additional 3 (1 in group A and 2 in group B) discontinued the ORS before the end of the study at 6 months. At the end of the study, 19 remained. The mean taste rating given by the participants was, on a scale of 1–10, 7.3 ± 1.9 for group A and 7.6 ± 1.6 for group B ( P = .61). The mean number of days that ORSs were consumed each week was 6.0 ± 1.3 for group A and 6.6 ± 1 days for group B ( P = .06). Conclusion: Taste rating was not different for both ORSs; however, a significant number of participants did not complete the study.