Mechanically-driven bone remodeling simulation: Application to LIPUS treated rat calvarial defects. (October 2017)

• Record Type: Journal Article
• Authors: Scala, Ilaria; Spingarn, Camille; Rémond, Yves; Madeo, Angela; George, Daniel
• Is Part Of: Mathematics and mechanics of solids. Volume 22:Number 10(2017)
• Page Start: 1976
• Page End: 1988
• Publication Date: 2017-10
• Subjects: Mechanical-biological coupling -- growth resorption process -- continuum mixture model -- LIPUS driven bone growth; Materials -- Mechanical properties -- Periodicals; Solids -- Periodicals; Materials science -- Mathematics -- Periodicals; 620.11205
• DOI: 10.1177/1081286516651473
• Languages: English
• ISSNs: 1081-2865

Abstract

In this paper we numerically simulate the phenomenon of bone growth in bone defects as driven by external mechanical excitation. Bone growth is accounted for through a continuum model that allows simulation of the filling of a defect. The influence of the model boundary conditions is also discussed. Two and three dimensional simulations are presented, explicitly showing the bone regeneration process inside the cavity on a weekly basis. Numerical results are qualitatively compared with literature experimental data from a rat calvarial defect exposed to low-intensity pulsed ultrasound. The obtained results show trend correlations with the targeted phenomenological observations and allow us to perform a first evaluation of the proposed model parameters to be optimized for clinically relevant situations, even if a systematic experimental campaign is still needed to precisely identify the bio-mechanical parameters involved.