Evolutionary implication of B-1 lineage cells from innate to adaptive immunity. (January 2016)

• Record Type: Journal Article
• Authors: Zhu, Lv-yun; Shao, Tong; Nie, Li; Zhu, Ling-yun; Xiang, Li-xin; Shao, Jian-zhong
• Is Part Of: Molecular immunology. Volume 69(2016:Jan.)
• Page Start: 123
• Page End: 130
• Publication Date: 2016-01
• Subjects: VLR variable lymphocyte receptor -- BCR B cell receptor -- TCR T cell receptor -- mIgM membrane IgM -- APCs antigen-presenting cells -- CMPs common myelo-erythroid progenitors -- CLPs common lymphoid progenitors; B-1 cells -- B-2 cells -- Macrophages -- Evolution of B cells -- Evolution of adaptive immunity; Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2015.10.014
• Languages: English
• ISSNs: 0161-5890

Abstract

Highlights: We summarize the advances in B-1 lineage cell features from fish to mammals. We compare the B-1 lineage cell features to those of macrophages and B-2 cells. We determine the evolutionary connection of B-1 lineage cells between innate and adaptive immunities. Abstract: The paradigm that B cells mainly play a central role in adaptive immunity may have to be reevaluated because B-1 lineage cells have been found to exhibit innate-like functions, such as phagocytic and bactericidal activities. Therefore, the evolutionary connection of B-1 lineage cells between innate and adaptive immunities have received much attention. In this review, we summarized various innate-like characteristics of B-1 lineage cells, such as natural antibody production, antigen-presenting function in primary adaptive immunity, and T cell-independent immune responses. These characteristics seem highly conserved between fish B cells and mammalian B-1 cells during vertebrate evolution. We proposed an evolutionary outline of B cells by comparing biological features, including morphology, phenotype, ontogeny, and functional activity between B-1 lineage cells and macrophages or B-2 cells. The B-1 lineage may be a transitional cell type between phagocytic cells ( e.g ., macrophages) and B-2 cells that functionally connects innate and adaptive immunities. Our discussion would contribute to the understanding on the origination of B cells specialized in adaptive immunity from innate immunity. The results might provide further insight into the evolution of the immune system as a whole.