Novel fullerene derivatives as dual inhibitors of Hepatitis C virus NS5B polymerase and NS3/4A protease. Issue 19 (1st October 2016)

• Record Type: Journal Article
• Authors: Kataoka, Hiroki; Ohe, Tomoyuki; Takahashi, Kyoko; Nakamura, Shigeo; Mashino, Tadahiko
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 19(2016)
• Page Start: 4565
• Page End: 4567
• Publication Date: 2016-10-01
• Subjects: HCV Hepatitis C virus -- NS non-structural; Fullerene -- Hepatitis C virus (HCV) -- NS3/4A protease -- NS5B polymerase; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.08.086
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: We evaluated the Hepatitis C virus (HCV) NS5B polymerase and HCV NS3/4A protease inhibition activities of a new set of proline-type fullerene derivatives. All of the compounds had the potential to inhibit both the enzymes, indicating that the fullerene derivatives may be dual inhibitors against NS5B and NS3/4A and could be novel lead compounds for the treatment of HCV infections.