Controlled arterial reflow after ischemia induces better outcomes in the juvenile rat brain. Issue 9 (September 2017)

• Record Type: Journal Article
• Authors: Bonnin, Philippe; Pansiot, Julien; Paven, Elise; Eloi, Maxime; Renolleau, Sylvain; Baud, Olivier; Leger, Pierre-Louis; Charriaut-Marlangue, Christiane
• Is Part Of: Journal of cerebral blood flow & metabolism. Volume 37:Issue 9(2017)
• Page Start: 3091
• Page End: 3096
• Publication Date: 2017-09
• Subjects: Ischemic stroke -- macrocirculation -- arterial re-flow -- cell death; Cerebral circulation -- Periodicals; Brain -- Metabolism -- Periodicals; Brain -- Blood-vessels -- Periodicals; Cerebrovascular disease -- Periodicals; 612.824
• DOI: 10.1177/0271678X17719614
• Languages: English
• ISSNs: 0271-678X

Abstract

Our objective was to determine whether controlled reflow on one side and/or the other side after bilateral carotid occlusion release could reduce cell death in focal ischemic P14 rats. Arterial blood flow was measured using ultrasonography. Cell death, inflammation and nitrotyrosine were measured using immunofluorescence. When reflow was first induced in the contralateral side, we observed improved outcome markers compared with those when reflow was first induced in the ipsilateral side and/or simultaneous reflow was induced in both sides. Our data suggest that progressive rerouting of arterial flow through the circle of Willis toward the ischemic site reduced cell death.