Enhanced osteoblast cells adhesion, spreading, and proliferation to surface-carboxylated poly(etheretherketone). (May 2015)

• Record Type: Journal Article
• Authors: Zheng, Yanyan; Xiong, Chengdong; Wang, Zhecun; Zhang, Lifang
• Is Part Of: Journal of bioactive and compatible polymers. Volume 30:Number 3(2015:May)
• Page Start: 302
• Page End: 318
• Publication Date: 2015-05
• Subjects: Poly(etheretherketone) -- surface modification -- carboxyl groups -- osteoblast cells -- biomaterials; Biomedical materials -- Periodicals; Polymers in medicine -- Periodicals; Polymers -- Periodicals; 547.7
• DOI: 10.1177/0883911515572494
• Languages: English
• ISSNs: 0883-9115

Abstract

Poly(etheretherketone) is a rigid semicrystalline thermoplastic that combines excellent mechanical properties, broad chemical resistance, and bone-like stiffness, and is widely used in biomedical fields. However, the hydrophobic bio-inert surface of poly(etheretherketone) tends to hinder its biomedical applications when direct osteointegration between the implants and the host tissue is desired. In this investigation, poly(etheretherketone) surface was functionalized by a method with chemistry analogous to the formation of organosilane self-assembled monolayers on glass or silicon. First, poly(etheretherketone) surface activation with selective carbonyl reduction introduces surface hydroxylation. And then treatment of the hydroxylation-pretreated poly(etheretherketone) samples with a substituted organosilane solution forms the carboxyl (–COOH) functional surface layers. The modified surfaces were characterized using X-ray photoelectron spectroscopy, water contact angle measurements, differential scanning calorimetry, X-ray diffraction, and surface profiler. The effect of cell adhesion, spreading, and proliferation on each specimen was investigated. Pre-osteoblast cells (MC3T3-E1) adhesion, spreading, and proliferation were improved remarkably on surface-carboxylated poly(etheretherketone). Poly(etheretherketone) modified with –COOH on its surface has potential use in orthopedic or dental implants.