Historical aspects of botulinum toxin used clinically: part II: overcoming resistance. (2015)

• Record Type: Journal Article
• Authors: Pickett, Andy
• Is Part Of: Botulinum journal. Volume 3:Number 1(2015)
• Page Start: 34
• Page End: 40
• Publication Date: 2015
• Subjects: botulinum neurotoxins -- BoNT -- historical notes -- second serotype -- botulism -- clinical use -- drug resistance -- drug immune -- Clostridium botulinum -- botulinum toxin serotype; Botulinum toxin -- Periodicals; Clostridium botulinum -- Periodicals; Drug development -- Periodicals; 615.9529364
• Languages: English
• ISSNs: 1754-7318

Abstract

After the extraordinary success of botulinum toxin serotype A in the 1980s to treat a wide range of spasmodic muscular conditions and movement disorders, a significant number of patients were found to stop responding to their treatments with time. When investigated, they were found to have become immune ('resistant') to the products. This second article in a series looks at the next botulinum toxin serotype used clinically after serotype A to overcome this resistance and how that choice was made.