Anti-adipogenic and anti-diabetic effects of cis-3′, 4′-diisovalerylkhellactone isolated from Peucedanum japonicum Thunb leaves in vitro. Issue 19 (1st October 2016)

• Record Type: Journal Article
• Authors: Choi, Ra-Yeong; Nam, Sang-Jip; Ham, Ju Ri; Lee, Hae-In; Yee, Sung-Tae; Kang, Kyung-Yun; Seo, Kwon-Il; Lee, Ju-Hye; Kim, Myung-Joo; Lee, Mi-Kyung
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 19(2016)
• Page Start: 4655
• Page End: 4660
• Publication Date: 2016-10-01
• Subjects: Adipocytes -- Adipogenesis -- Anti-diabetes -- Anti-obesity -- Peucedanum japonicum Thunb leaves; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.08.056
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Peucedanum japonicum Thunb is a medicinal plant belonging to the family Umbelliferae. This study evaluated the anti-diabetic and anti-obesity effects of cis -3′, 4′-diisovalerylkhellactone (cDIVK) isolated from Peucedanum japonicum Thunb leaves. cDIVK (30 and 50 μM) effectively inhibited adipocyte differentiation and fat accumulation, whereas it stimulated glucose uptake compared with the control in 3T3-L1 cells. cDIVK significantly increased AMPK activation and suppressed protein and mRNA expression of major adipogenic transcriptional factors such as C/EBPα, PPARγ and SREBP-1c in 3T3-L1 cells. In addition, cDIVK had potential α-glucosidase inhibitory activity. These results indicated that cDIVK may act as a natural dual therapeutic agent for diabetes and obesity.