Lipoprotein-Associated Phospholipase A2 and Risk of Carotid Atherosclerosis and Cardiovascular Events in Community-Based Older Adults in China. (January 2018)

• Record Type: Journal Article
• Authors: Wang, Chunxiu; Fang, Xianghua; Hua, Yang; Liu, Yutong; Zhang, Zhongying; Gu, Xiang; Wu, Xiaoguang; Tang, Zhe; Guan, Shaochen; Liu, Hongjun; Liu, Beibei; Guo, Xiuhai; Ji, Xunming
• Is Part Of: Angiology. Volume 69:Number 1(2018)
• Page Start: 49
• Page End: 58
• Publication Date: 2018-01
• Subjects: lipoprotein-associated phospholipase A2 -- cardiovascular disease -- carotid atherosclerosis -- myocardial infarction -- stroke; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319717704554
• Languages: English
• ISSNs: 0003-3197

Abstract

We explored the associations between lipoprotein-associated phospholipase A2 (Lp-PLA2) level and carotid atherosclerosis with all phenotypes and cardiovascular disease (CVD) events in Chinese older adults. A total of 1257 adults aged ≥55 years who were free of CVD were enrolled in this cohort study. Lipoprotein-associated phospholipase A2 level was evaluated in 3 categories: Lp-PLA2 < 175, 175≤ Lp-PLA2 < 223, and Lp-PLA2 ≥ 223 ng/mL. The highest level of Lp-PLA2 was independently associated with common carotid artery intima-media thickening (≥1.0 mm; odds ratio [OR]: 1.60, 95% confidence interval [CI]: 1.14-2.26) and carotid plaque (OR: 1.42, 95% CI: 1.01-1.99) in individuals without carotid artery stenosis. At the end of the 5-year follow-up, after adjustment for CVD risk factors and carotid atherosclerosis status, Lp-PLA2 had remained an independent predictor for myocardial infarction (MI; hazard ratio [HR]: 1.90, 95% CI: 1.02-3.55) and CVD death (HR: 1.78, 95% CI: 1.02-3.13). However, no association was found with stroke. Therefore, elevated Lp-PLA2 level in the older adults studied was associated with an increased risk of carotid atherosclerosis and MI and CVD mortality. Lipoprotein-associated phospholipase A2 assessment might be used for MI and CVD death risk prediction.