Asymmetric synthesis of 3, 4-dihydro-2H-1, 2, 4-benzothiadiazine-1, 1- dioxides catalyzed by scandium(III)-inda-Pybox. Issue 12 (24th March 2016) - Du, Peng
Abstract: Asymmetric synthesis of 3, 4-dihydro-2 H -1, 2, 4-benzothiadiazine-1, 1-dioxides (DHBDs) was realized using readily available scandium(III)- inda -Pybox as the catalyst. It represents the first example focusing on systematic study of asymmetric synthesis of DHBDs, and a series of enantioselective 3-alkyl, or 3-aryl DHBDs were obtained with up to 93% ee. Graphical abstract: