Abscopal effect of radiation on bone metastases of breast cancer: A case report. Issue 1 (2nd January 2018)

• Record Type: Journal Article
• Authors: Leung, Henry WC; Wang, Shyh-Yau; Jin-Jhih, Huang; Chan, Agnes LF
• Is Part Of: Cancer biology & therapy. Volume 19:Issue 1(2018)
• Page Start: 20
• Page End: 24
• Publication Date: 2018-01-02
• Subjects: Abscopal effect -- bone metastases -- radiotherapy -- breast cancer spontaneous regression; 616.99406
• DOI: 10.1080/15384047.2017.1394545
• Languages: English
• ISSNs: 1538-4047

Abstract

Abstract : The abscopal effect is defined as the clearance of distant tumors after applying localized irradiation to a particular tumor site. It has been proposed that a mechanism for the abscopal effect might be the activation of the immune system, which leads to immunogenic tumor cell death. Here, we describe a woman with advanced breast cancer that received modified ablative radiation therapy that targeted her primary breast tumor. She experienced an apparent regression of metastatic mass in the thoracic spine. This case supported the hypothesis that the abscopal effect might be attributable to an activation of the systemic immune response.