Animal behavioral assessments in current research of Parkinson's disease. (June 2016)

• Record Type: Journal Article
• Authors: Asakawa, Tetsuya; Fang, Huan; Sugiyama, Kenji; Nozaki, Takao; Hong, Zhen; Yang, Yilin; Hua, Fei; Ding, Guanghong; Chao, Dongman; Fenoy, Albert J.; Villarreal, Sebastian J; Onoe, Hirotaka; Suzuki, Katsuaki; Mori, Norio; Namba, Hiroki; Xia, Ying
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 65(2016)
• Page Start: 63
• Page End: 94
• Publication Date: 2016-06
• Subjects: 6-OHDA 6-hydroxydopamine -- AIMS abnormal involuntary movement scale -- DA dopamine -- DBS deep brain stimulation -- FRT food reaching test -- FST forced swimming test -- LB Lewy body -- LRRK2 leucine-rich repeat kinase 2 -- MCMCT Michigan complex motor control test -- MPTP 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine -- NHP nonhuman primate -- OF open field -- OFT open field test -- OMS objectification -- PD Parkinson's disease -- PDRS Parkinson's disease rating scale -- UPDRS unified Parkinson's disease rating scale; Behavioral assessments -- Fine motor -- Free-moving counting -- Food reaching movement -- Locomotion motor symptoms -- Non-motor symptoms -- Parkinsonian model -- Neuropsychological tasks; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2016.03.016
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: Assessments should include motor- and non-motor symptoms. Assessments covering all animal models were discussed. Bias should be avoided during the experimental design. Principles of OMS are important in the experimental design for behavioral assessments. Abstract: Parkinson's disease (PD), a neurodegenerative disorder, is traditionally classified as a movement disorder. Patients typically suffer from many motor dysfunctions. Presently, clinicians and scientists recognize that many non-motor symptoms are associated with PD. There is an increasing interest in both motor and non-motor symptoms in clinical studies on PD patients and laboratory research on animal models that imitate the pathophysiologic features and symptoms of PD patients. Therefore, appropriate behavioral assessments are extremely crucial for correctly understanding the mechanisms of PD and accurately evaluating the efficacy and safety of novel therapies. This article systematically reviews the behavioral assessments, for both motor and non-motor symptoms, in various animal models involved in current PD research. We addressed the strengths and weaknesses of these behavioral tests and their appropriate applications. Moreover, we discussed potential mechanisms behind these behavioral tests and cautioned readers against potential experimental bias. Since most of the behavioral assessments currently used for non-motor symptoms are not particularly designed for animals with PD, it is of the utmost importance to greatly improve experimental design and evaluation in PD research with animal models. Indeed, it is essential to develop specific assessments for non-motor symptoms in PD animals based on their characteristics. We concluded with a prospective view for behavioral assessments with real-time assessment with mobile internet and wearable device in future PD research.