Interaction of methimazole/curcumin with human serum albumin: Partial molar volume and partial molar isentropic compressibility studies. (December 2015)

• Record Type: Journal Article
• Authors: Afrin, Sadaf; uddeen, Riyaz
• Is Part Of: Journal of chemical thermodynamics. Volume 91(2015:Dec.)
• Page Start: 80
• Page End: 85
• Publication Date: 2015-12
• Subjects: Human serum albumin -- Methimazole -- Curcumin -- Isentropic compressibility -- Partial molar volume -- Partial molar isentropic compressibility; Thermodynamics -- Periodicals; Thermochemistry -- Periodicals; Thermodynamique -- Périodiques; Thermochimie -- Périodiques; Thermochemistry; Thermodynamics; Periodicals; 541.369
• DOI: 10.1016/j.jct.2015.07.001
• Languages: English
• ISSNs: 0021-9614

Abstract

Graphical abstract: Isentropic compressibilities ( k s ) of the methimazole in 25 μmol · kg −1 HSA as a function of concentration at temperatures: ■, 298.15 K;, 303.15 K;, 308.15 K;, 313.15 K;, 318.15 K and, 323.15 K. Highlights: V ϕ 0 and k s ϕ 0 values of methimazole/curcumin in HSA solutions have been determined. V ϕ 0, k s ϕ 0 have been discussed in terms of electrostatic and hydrophobic interactions. k s ϕ have been discussed in terms of structure breaking behavior of drugs. Abstract: Partial molar volume ( V ϕ 0 ) and partial molar isentropic compressibility ( κ s ϕ 0 ) values of drugs methimazole and curcumin in 25 μmol · kg −1 human serum albumin (HSA) solution have been evaluated using density and speed of sound data. The isentropic compressibility values ( ϕ κ s ) of (curcumin/methimazole + HSA) solutions have also been computed. The ϕ κ s values decrease with an increase in the molal concentration of drugs as well as with temperature. The variations of trends of ϕ κ s for the studied drugs have been discussed in terms of structure breaking behavior of drugs. The values of V ϕ 0 and κ s ϕ 0 have been interpreted in terms of electrostatic and hydrophobic interactions operative in the solutions.