Measurement of nasal and fractional exhaled nitric oxide in children with upper airway inflammatory disease: Preliminary results. Issue 12 (December 2015)

• Record Type: Journal Article
• Authors: Liu, Dabo; Huang, Zhenyun; Huang, Yaping; Yi, Xinhua; Chen, Xi
• Is Part Of: International journal of pediatric otorhinolaryngology. Volume 79:Issue 12(2015:Dec.)
• Page Start: 2308
• Page End: 2311
• Publication Date: 2015-12
• Subjects: Nasal nitric oxide -- Fractional exhaled nitric oxide -- Sleep disordered breathing -- Allergic rhinitis; Otolaryngology -- Periodicals; Pediatrics -- Periodicals; Otolaryngology -- Periodicals; Pediatrics -- Periodicals; Oto-rhino-laryngologie -- Périodiques; Pédiatrie -- Périodiques; 618.9209751
• DOI: 10.1016/j.ijporl.2015.10.033
• Languages: English
• ISSNs: 0165-5876

Abstract

Abstract: Objectives: To assess the clinical significance of nasal nitric oxide (nNO) and fractional exhaled nitric oxide (FeNO) concentrations in children with upper airway inflammatory disease. Methods: Fifteen healthy children, 30 with allergic rhinitis (AR), 10 with non-allergic rhinitis (NAR), and 30 with sleep disordered breathing (SDB) were enrolled. The FeNO and nNO concentrations were measured non-invasively using a NIOX MINO system. Results: Both nNO and FeNO were significantly higher in children with AR than in healthy children ( P = 0.000 and P = 0.000, respectively). Compared to healthy children, nNO was also significant higher in children with NAR ( P = 0.011) or SDB ( P = 0.027). In contrast, FeNO did not differ from controls in children with NAR or SDB. Conclusions: Our data suggest that nNO has potential value for diagnosing upper airway inflammation. Moreover, elevated FeNO distinguishes allergic from non-allergic rhinitis.