APOE ε4 and Memory Among Patients With Heart Failure. (April 2017)

• Record Type: Journal Article
• Authors: Pressler, Susan J.; Harrison, Jordan M.; Titler, Marita; Koelling, Todd M.; Jung, Miyeon; Dorsey, Susan G.; Bakoyannis, Giorgos; Riley, Penny L.; Hoyland-Domenico, Lisa; Giordani, Bruno
• Other Names: Moser Debra K. guest-editor.
• Is Part Of: Western journal of nursing research. Volume 39:Number 4(2017)
• Page Start: 455
• Page End: 472
• Publication Date: 2017-04
• Subjects: heart failure -- memory -- cognition -- apolipoprotein E -- APOE ε4 -- brain-derived neurotrophic factor -- BDNF; Nursing -- Research -- Periodicals; Nursing -- Periodicals; Nursing -- Research -- West (U.S.) -- Periodicals; Nursing -- West (U.S.) -- Periodicals; Nursing -- Periodicals; Nursing Research -- Periodicals; Soins infirmiers -- Recherche -- Périodiques; Soins infirmiers -- Périodiques; Soins infirmiers -- Recherche -- États-Unis (Ouest) -- Périodiques; Soins infirmiers -- États-Unis (Ouest) -- Périodiques; Soins infirmiers; Recherche; États-Unis (Ouest); Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 610.730702
• DOI: 10.1177/0193945916670145
• Languages: English
• ISSNs: 0193-9459

Abstract

Twenty-three percent to 50% of heart failure (HF) patients have memory loss. Objectives were to (a) characterize major allelic frequency of 2 variants in apolipoprotein ( APOE ) gene in HF patients, (b) evaluate differences in memory and serum brain-derived neurotrophic factor (BDNF) levels based on APOE ε4 allele(s), and (c) estimate effect sizes (ESs) and confidence intervals (CIs). In this pilot, 29 HF patients were enrolled and 26 completed. Recall and delayed recall memory were measured at baseline and 12 weeks. Serum was collected at baseline and 8 weeks. Seven (24.1%) patients had APOE ε4 allele. No significant differences were found in recall and delayed recall memory or serum BDNF levels based on APOE ε4 allele. ESs were small to medium; CIs indicated ES precision was small. Future studies are needed to fully understand how genotypic and neuropsychological phenotypic variables influence response to computerized cognitive training.