Big Data Cohort Extraction to Facilitate Machine Learning to Improve Statin Treatment. (January 2017)

• Record Type: Journal Article
• Authors: Chi, Chih-Lin; Wang, Jin; Clancy, Thomas R.; Robinson, Jennifer G.; Tonellato, Peter J.; Adam, Terrence J.
• Is Part Of: Western journal of nursing research. Volume 39:Number 1(2017)
• Page Start: 42
• Page End: 62
• Publication Date: 2017-01
• Subjects: Big Data -- machine learning -- cohort extraction -- statin treatment -- translational research; Nursing -- Research -- Periodicals; Nursing -- Periodicals; Nursing -- Research -- West (U.S.) -- Periodicals; Nursing -- West (U.S.) -- Periodicals; Nursing -- Periodicals; Nursing Research -- Periodicals; Soins infirmiers -- Recherche -- Périodiques; Soins infirmiers -- Périodiques; Soins infirmiers -- Recherche -- États-Unis (Ouest) -- Périodiques; Soins infirmiers -- États-Unis (Ouest) -- Périodiques; Soins infirmiers; Recherche; États-Unis (Ouest); Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 610.730702
• DOI: 10.1177/0193945916673059
• Languages: English
• ISSNs: 0193-9459

Abstract

Health care Big Data studies hold substantial promise for improving clinical practice. Among analytic tools, machine learning (ML) is an important approach that has been widely used by many industries for data-driven decision support. In Big Data, thousands of variables and millions of patient records are commonly encountered, but most data elements cannot be directly used to support decision making. Although many feature-selection tools can help identify relevant data, these tools are typically insufficient to determine a patient data cohort to support learning. Therefore, domain experts with nursing or clinic knowledge play critical roles in determining value criteria or the type of variables that should be included in the patient cohort to maximize project success. We demonstrate this process by extracting a patient cohort (37, 506 individuals) to support our ML work (i.e., the production of a proactive strategy to prevent statin adverse events) from 130 million de-identified lives in the OptumLabs™ Data Warehouse.