Amphiphilic photosensitive dextran-g-poly(o-nitrobenzyl acrylate) glycopolymers. (20th January 2016)

• Record Type: Journal Article
• Authors: Soliman, Soliman Mehawed Abdellatif; Colombeau, Ludovic; Nouvel, Cécile; Babin, Jérôme; Six, Jean-Luc
• Is Part Of: Carbohydrate polymers. Volume 136(2016)
• Page Start: 598
• Page End: 608
• Publication Date: 2016-01-20
• Subjects: 2-Nitrobenzyl acrylate -- CRP -- RDRP -- Grafted copolymer -- Photo-responsive polymer -- Biodegradable; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2015.09.061
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: o -Nitrobenzyl acrylate (NBA) was polymerized in a controlled way by SET–LRP. Azido-terminated PNBA were produced according two strategies. Dex- g -PNBA were obtained by CuAAC with PNBA weight fraction from 22% to 85%. Photosensitive property of Dex- g -PNBA was studied under UV irradiation. Under UV, hydrophobic PNBA grafts turn to hydrophilic poly(acrylic acid) ones. Abstract: Among all photosensitive monomers reported in the literature, o -nitrobenzyl acrylate (NBA) was selected in this present study. Two strategies were compared to produce azido-terminated poly( o -nitrobenzyl acrylate) (PNBA) using controlled Single Electron Transfer-Living Radical Polymerization (SET-LRP). In a parallel way, dextran (Dex) was modified by the introduction of several alkynyl-terminated hydrophobic chains. Finally, an Huisgen-type Copper (I)-catalyzed Azide–Alkyne Cycloaddition (CuAAC) click-chemistry was carried out to produce amphiphilic Dex- g -PNBA glycopolymers with different number and length of PNBA grafts. 2D DOSY 1 H NMR was used to prove the formation of such glycopolymers. Preliminary study on Dex- g -PNBA self-assembly was done by measuring the critical water content (CWC) above which Dex- g -PNBA started to auto-organize themselves to produce nano-objects. Finally, under UV irradiation, PNBA grafts turn into poly(acrylic acid) ones giving light-sensitive properties to such amphiphilic Dex- g -PNBA. Such properties were evaluated and compared with those of PNBA.