Synthesis, antioxidant and cathepsin D inhibition activity of quaternary ammonium chitosan derivatives. (20th January 2016)

• Record Type: Journal Article
• Authors: Li, Wenjuan; Duan, Yunfei; Huang, Jianying; Zheng, Qunxiong
• Is Part Of: Carbohydrate polymers. Volume 136(2016)
• Page Start: 884
• Page End: 891
• Publication Date: 2016-01-20
• Subjects: Chitosan -- Quaternary ammonium -- Imidazole -- Antioxidant activity -- Cathepsin D inhibitor; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2015.09.111
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Two quaternary ammonium chitosan derivatives were synthesized and characterized. The solubility and antioxidant activity of the resulting polymer were improved. Well cathepsin D inhibition activity was further demonstrated. They are potential to be used in food and pharmaceutical industries. Abstract: Two (2-hydroxypropyl) trimethyl ammonium and/or imidazole-based quaternary ammonium chitosan derivatives (NHT-chitosan and Im-OHT-chitosan) were synthesized by using nucleophilic substitution reaction. These two synthesized chitosan derivatives were characterized by Fourier transform infrared spectroscopy, NMR spectra, and UV–visible spectra. The applications as antioxidant agents and cathepsin D inhibitors were further investigated. Both of quaternary ammonium chitosan derivatives exhibited good antioxidant activity upon scavenging against hydroxyl radical and hydrogen peroxide as well as the lipid peroxidation inhibition in the linoleic acid emulsion system. They also exhibited good inhibition activity of cathepsin D protease. NHT-chitosan and Im-OHT-chitosan are potential the natural, healthy and safe preservatives in food industry.