Surface fluid-swellable chitosan fiber as the wound dressing material. (20th January 2016)

• Record Type: Journal Article
• Authors: Xia, Guixue; Lang, Xuqian; Kong, Ming; Cheng, Xiaojie; Liu, Ya; Feng, Chao; Chen, Xiguang
• Is Part Of: Carbohydrate polymers. Volume 136(2016)
• Page Start: 860
• Page End: 866
• Publication Date: 2016-01-20
• Subjects: Surface fluid-swellable chitosan -- Fiber -- Wound dressing; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2015.09.074
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: The surface fluid-swellable chitosan (SFSC) fiber showed better liquid absorption. The SFSC fiber had synergistic antibacterial activity. The SFSC fiber was compatible with mouse embryo fibroblasts. The SFSC fiber could potentially be used as wound dressing. Abstract: The objective of this study was to develop a novel surface fluid-swellable chitosan (SFSC) fiber for potential wound dressing. The SFSC fiber was successfully prepared by surface modification of chitosan fiber with succinic anhydride, which was characterized by FTIR and solid-state 13 C NMR. The SFSC fiber exhibited better water absorption capacity (approx. 2980%) and stronger antibacterial activities (both above 90%) against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) than chitosan fiber (both below 75%). The cell viability was more than 90% after treated with the SFSC fiber extract, which demonstrated that SFSC fiber had low cytotoxicity towards mouse embryo fibroblasts (MEFs). The SFSC fiber could promote wound healing with advanced development of granulation tissue and epithelial coverage compared with the control (gauze-covered) group. The results indicated that SFSC fiber had great potential to be used as wound dressing material.