Synthesis and decreasing Aβ content evaluation of arctigenin-4-yl carbamate derivatives. Issue 13 (1st July 2016) - Xu, Xingyu
Graphical abstract: Abstract: A series of arctigenin-4-yl carbamate derivatives were synthesized and evaluated for potency in reducing β -amyloid (A β ) content in HEK293-APPswe cells. Most of the arctigenin-4-yl aralkyl or aryl carbamate derivatives showed improved potency in reducing A β content. Among the synthesized compounds, arctigenin-4-yl (3-chlorophenyl)carbamate (20 ) exhibited the strongest potency with 78.7% A β content reduction at 20 μM. Furthermore, the effect of arctigenin-4-yl (4-chlorophenyl)carbamate (19 ) and arctigenin-4-yl (3-chlorophenyl)carbamate (20 ) on lowing A β content was better than arctigenin under the concentrations of 1, 10 and 20 μM.