Iron(III) salicylates of dipicolylamine bases showing photo-induced anticancer activity and cytosolic localization. (14th December 2015)

• Record Type: Journal Article
• Authors: Garai, Aditya; Pant, Ila; Kondaiah, Paturu; Chakravarty, Akhil R.
• Is Part Of: Polyhedron. Volume 102(2015)
• Page Start: 668
• Page End: 676
• Publication Date: 2015-12-14
• Subjects: Iron -- Salicylic acid -- Crystal structure -- Photocytotoxicity -- Cellular imaging; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2015.10.026
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: An iron(III) salicylate having a dipicolylamine base with anthracenyl pendant shows cytosolic localization, remarkable photo-induced cytotoxicity and apoptotic cell death. Abstract: An iron(III) salicylate having a dipicolylamine base (andpa) with a photoactive anthracenyl moiety is prepared, characterized, and studied for its photo-induced anticancer activity and cellular localization in HeLa and MCF-7 cells. Its phenyl analogue is structurally characterized by X-ray crystallography. The complex has a ternary structure in which the dipicolylamine ligand and salicylic acid in dianionic form (sal) display respective tridentate and bidentate mode of coordination in [Fe(sal)(phdpa)Cl] (1 ). Complex [Fe(sal)(andpa)Cl] (2 ) having a pendant anthracenyl moiety shows significant photocytotoxicity in visible light (400–700 nm) giving IC50 values of 8.6 ± 0.7 and 3.4 ± 0.9 μM in HeLa and MCF-7 cells, while being essentially nontoxic in the dark (IC50 > 100 μM). The complex shows cytosolic localization in the cancer cells. Formation of hydroxyl radicals ( OH) as the reactive oxygen species is evidenced from the pUC19 DNA photocleavage studies.