Primary mediastinal synovial sarcoma: A rare case report. (2016)

• Record Type: Journal Article
• Authors: Ershadi, Reza; Rahim, Mohamadbagher; Davari, Hamidreza
• Is Part Of: International journal of surgery case reports. Volume 27(2016)
• Page Start: 169
• Page End: 171
• Publication Date: 2016
• Subjects: Mediastinal synovial sarcoma -- Mediastinal mass -- Immunohistochemistry; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; Surgery; Electronic journals; Periodicals; 617.005
• DOI: 10.1016/j.ijscr.2016.08.037
• Languages: English
• ISSNs: 2210-2612

Abstract

Highlights: Synovial sarcomas commonly occur in the extremities of young adults. A primary occurrence in the mediastinum is very rare with only a few reported cases in the world literature. This paper highlights the importance of recognizing an unusual presentation of this aggressive neoplasm to aid appropriate clinical management. Abstract: Introduction: Synovial sarcomas commonly occur in the extremities of young adults. A primary occurrence in the mediastinum is very rare with only a few reported cases in the world literature. We report a case of mediastinal synovial sarcoma. This paper is about a 47-year-old male who presented with retrosternal chest pain and shortness of breath on exertion. Imaging showed an anterior mediastinal mass. Pathological examination of the resected mass showed a biphasic neoplasm with a spindle cell component admixed with gland-like elements. The tumor showed positive staining with cytokeratin, epithelial membrane antigen and vimentin confirming the diagnosis of a biphasic synovial sarcoma. Discussion: A wide range of neoplasms, both primary and metastatic, occur in the mediastinum, which pose considerable diagnostic difficulties. A synovial sarcoma should always be considered in the differential diagnosis, and immunohistochemistry is an important adjuvant tool in this situation. Conclusion: This paper highlights the importance of recognizing an unusual presentation of this aggressive neoplasm to aid appropriate clinical management.