Orosomucoid as prognosis factor associated with inflammation in acute or nutritional status in chronic heart failure. (1st February 2017)

• Record Type: Journal Article
• Authors: Agra, Rosa M; Varela-Román, Alfonso; González-Ferreiro, Rocío; Viñuela, Juan E.; Castro-Pais, Ana; Fernández-Trasancos, Ángel; Díaz-Rodríguez, Esther; Álvarez, Ezequiel; Carreira, Marcos C; Casanueva, Felipe F; González-Juanatey, José R; Eiras, Sonia
• Is Part Of: International journal of cardiology. Volume 228(2017)
• Page Start: 488
• Page End: 494
• Publication Date: 2017-02-01
• Subjects: HF heart failure -- AHF acute heart failure -- CHF chronic heart failure -- AGP alpha-1-acid-glycoprotein -- CRP C-reactive protein -- TNF-α tumor necrosis factor -- EAT epicardial adipose tissue -- DEXA dual energy X-ray absorptiometry -- proBNP pro brain natriuretic peptide -- CONUT score controlling nutritional status score; AGP -- Heart failure -- Inflammation -- Epicardial adipose tissue; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2016.11.134
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: Inflammation and nutritional state are involved in the pathogenesis of heart failure (HF). Objective: To study the contribution of alpha-1-acid-glycoprotein (AGP) to these factors and its prognostic value in acute (AHF) or chronic HF (CHF). Methods: The observational study has included 147 patients (mean age 70 years, 62% men) admitted to a cardiology department for HF and followed-up for an average 326.6 ± 140.8 days. Blood AGP values were measured by Enzyme-Linked ImmunoSorbent Assay. Monocytes subsets were determined with CD14 and CD16 antibodies by flow cytometry and body composition was measured by dual-energy X-ray absorptiometry. The regulation of tumor necrosis factor (TNF-α) and leptin by AGP in epicardial adipose tissue (EAT) were analyzed by real time polymerase chain reaction. Results: High AGP, that was associated with CD14 + CD16 + monocytes, and proBNP levels at the discharge were indicators of rehospitalization for HF in AHF patients. However, low AGP levels determined a worse nutritional state in CHF patients. The leptin levels were downregulated by high AGP concentration in epicardial fat. Conclusion: AGP is a dual indicator in HF because high levels are predictors of adverse outcomes in AHF but low levels are related to the worse nutritional status in CHF. The regulation of leptin by AGP in epicardial fat might suggest a new pathway as protective mechanism in CHF.