ID 284 – Abnormal delta cortical sources of resting state eyes closed EEG rhythms correlate with cerebrospinal fluid (CSF) ® amyloid (A®) level in amnesic MCI subjects. Issue 3 (March 2016)

• Record Type: Journal Article
• Authors: Noce, G.; Del Percio, C.; Marzano, N.; Cordone, S.; Bagnoli, C.; Rossini, P.M.; Soricelli, A.; Nobili, F.M.; Bartres Faz, D.; Blin, O.; Payoux, P.; Bordet, R.; Müller, B.W.; Tsolaki, M.; Parnetti, L.; Hegerl, U.; Hensch, T.; Dukar, J.; Bertolino, A.; Forloni, G.; Richardson, J.C.; Frisoni, G.; Babiloni, C.
• Is Part Of: Clinical neurophysiology. Volume 127:Issue 3(2016:Mar.)
• Page Start: e111
• Page End: e112
• Publication Date: 2016-03
• Subjects: Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2015.11.376
• Languages: English
• ISSNs: 1388-2457

Abstract

Abstract : Aim: In the framework of IMI PharmaCog project (Grant Agreement no. 115009), this study evaluated whether abnormal cortical sources of resting state electroencephalographic (EEG) rhythms are correlated to cerebrospinal fluid (CSF) ® amyloid (A®) level in amnesic Mild Cognitive Impairment (MCI) subjects. Methods: Artifact-free resting state eyes-closed EEG rhythms (19 electrodes) were recorded. Individual datasets were divided into those with high CSF A® level (81 A®-negative, CSF A ® > 550 pg / ml ) and those with low CSF A® level (46 A®-positive, CSF A ® < 550 pg / ml ). Regional normalized cortical sources of EEG rhythms at frequency bands of interest were estimated by LORETA package. ANOVA compared these sources between the two MCI groups ( p < 0.05, corrected) and 50 cognitively normal elderly (Nold) subjects. Results: Statistical results showed: (1) source pattern Nold < A®-negative < A®-positive at frontal, temporal and limbic delta sources level; (2) significant negative correlation (Pearson test, p < 0.05) between temporal delta sources and CSF A® level ( r = −0.26; p = 0.003) across all MCI subjects. Conclusions: These results suggest a relationship between the brain amyloid charge, as revealed by CSF A® level, and pathological delta cortical sources indicating cortical disconnection in amnesic MCI subjects. EEG delta sources could represent a promising early diagnostic marker of Alzheimer's disease (AD).