Development of silver sulfadiazine loaded bacterial cellulose/sodium alginate composite films with enhanced antibacterial property. (5th November 2015)

• Record Type: Journal Article
• Authors: Shao, Wei; Liu, Hui; Liu, Xiufeng; Wang, Shuxia; Wu, Jimin; Zhang, Rui; Min, Huihua; Huang, Min
• Is Part Of: Carbohydrate polymers. Volume 132(2015)
• Page Start: 351
• Page End: 358
• Publication Date: 2015-11-05
• Subjects: Bacterial cellulose -- Silver sulfadiazine -- Sodium alginate -- Antibacterial activity; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2015.06.057
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Bacterial cellulose/sodium alginate (BC/SA)–AgSD composites were successfully prepared. BC/SA–AgSD composites have pH-sensitive swelling behaviors. BC/SA–AgSD composites exhibited excellent antibacterial activities. BC/SA–AgSD composites showed good biocompatibility. The prepared composites have great potential application in wound dressing areas. Abstract: Sodium alginate (SA) and bacterial cellulose (BC) are widely used in many applications such as scaffolds and wound dressings due to its biocompatibility. Silver sulfadiazine (AgSD) is a topical antibacterial agents used as a topical cream on burns. In the study, novel BC/SA–AgSD composites were prepared and characterized by SEM, FTIR and TG analyses. These results indicate AgSD successfully impregnated into BC/SA matrix. The swelling behaviors in different pH were studied and the results showed pH-responsive swelling behaviors. The antibacterial performances of BC/SA–AgSD composites were evaluated with Escherichia coli, Staphylococcus aureus and Candida albicans . Moreover, the cytotoxicity of BC/SA–AgSD composites was performed on HEK 293 cells. The experimental results showed BC/SA–AgSD composites have excellent antibacterial activities and good biocompatibility, thus confirming its utility as potential wound dressings.