Emotional reactivity related to the electrode position changes along anterio-posterior direction in subthalamic stimulation for Parkinson's disease. Issue 3 (March 2016)

• Record Type: Journal Article
• Authors: Serranová, T.; Sieger, T.; Růžička, F.; Dušek, P.; Vostatek, P.; Št'astná, D.; Novák, D.; Růžička, E.; Urgošík, D.; Jech, R.
• Is Part Of: Clinical neurophysiology. Volume 127:Issue 3(2016:Mar.)
• Page Start: e33
• Publication Date: 2016-03
• Subjects: Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2015.11.102
• Languages: English
• ISSNs: 1388-2457

Abstract

Abstract : Objectives: Considering the functional organization of the subthalamic nucleus (STN), we hypothesized that STN-DBS might have a differential impact on emotional reactivity in relation to the electrode position within the STN. We aimed to assess this objectively using affective modulation of the acoustic blink reflex (ABR). Methods: ABR elicited during the viewing of rewarding, fearful and neutral pictures was recorded in 10 off-medicated PD patients with the STN-DBS switched ON and OFF. The active electrode contact positions in the STN were determined on T1-weighted MRI. The relation of ABR magnitude on DBS electrode position was assessed using linear regression. Results: The ABR magnitude from all picture categories was related to the electrode position in both the ON ( p < 0.01) and OFF-conditions ( p < 0.05) with larger ABRs associated with more anterior position. The ABR magnitude increase was present in the ON-condition even when adjusting for the OFF-condition ( p < 0.05), but not vice versa. Conclusions: The STN-DBS probably drove the electrode-position related effect on emotional activation along the anterio-posterior direction. This effect, however, was not stimulus category specific suggesting rather general increase in emotional arousal. Key message: Emotional reactivity changes due to DBS showed anterio-posterior gradient within the STN.