Association of serum organochlorine pesticides concentrations with reproductive hormone levels and polycystic ovary syndrome in a Chinese population. (March 2017)

• Record Type: Journal Article
• Authors: Guo, Zhizhun; Qiu, Huiling; Wang, Lingling; Wang, Lijun; Wang, Chonggang; Chen, Meng; Zuo, Zhenghong
• Is Part Of: Chemosphere. Volume 171(2017)
• Page Start: 595
• Page End: 600
• Publication Date: 2017-03
• Subjects: Polycystic ovary syndrome -- Organochlorine pesticides -- Endocrine disrupting -- Serum; BMI body mass index -- CVD cardiovascular disease -- DBP diastolic blood pressure -- DCM dichloromethane -- DDD dichlorodiphenyldichloroethane -- DDE dichlorodiphenyldichloroethylene -- DDT dichlorodiphenyltrichloroethane -- DHEAS dehydroepiandrosterone-sulfate -- E2 estradiol -- EDCs exogenous endocrine disrupting chemicals -- FSH follicle-stimulating hormone -- GC-MS-MS chromatography mass-mass spectrometer -- GIR fasting glucose/insulin ratio -- HCH hexachlorocyclohexane -- HDL-C high-density lipoprotein cholesterol -- HOMA homeostasis model assessment -- IR insulin resistance -- LDL-C low-density lipoprotein cholesterol -- LH luteinizing hormone -- LOD limit of detection -- OCPs organochlorine pesticides -- PCOS polycystic ovary syndrome -- PLS-DA partial least-squares-discriminant analysis -- POPs persistent organic pollutants -- PRL progesterone -- QUICKI quantitative insulin sensitivity check index -- SBP systolic blood pressure -- SHBG sex hormone binding globulin -- T2DM type 2 diabetes mellitus -- TSH thyroid-stimulating hormone -- WHR waist-to-hip ratio -- YLDs lived with disability; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2016.12.127
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: To investigate the serum concentrations of organochlorine pesticides (OCPs) in patients with polycystic ovary syndrome (PCOS), a total of 178 women were studied. The concentrations of hexachlorocyclohexane (HCH) and dichlorodiphenyltrichloroethane (DDT) in serum were determined using Gas Chromatography Mass-Mass Spectrometer. No differences with statistical significance in the mean HCH, p, p′ -DDD, p, p' -DDE concentrations were observed between the patients with PCOS and the control group. Serum p, p′ -DDT (P = 0.016) and o, p′ -DDT (P = 0.000) levels were significantly higher in patients with PCOS compared with the control group. The results of the association between OCPs levels and hormone levels indicated that o, p′ -DDT may play a role in the pathogenesis of PCOS by affecting hormones levels. Further trials should be investigated with the findings in this study to obtain new pathogenesis of PCOS. Highlights: PCOS is caused by a combination of genetic susceptibility and environmental exposures. Patients with PCOS had higher p, p′ -DDT (P = 0.016) and o, p′ -DDT levels than the controls. o, p′ -DDT may play a role in the pathogenesis of PCOS related with reproductive hormone levels.