Effect of PEGylated chitosan as multifunctional stabilizer for deacetyl mycoepoxydience nanosuspension design and stability evaluation. (20th November 2016)

• Record Type: Journal Article
• Authors: Du, Juan; Zhou, Yuqi; Wang, Lulu; Wang, Yancai
• Is Part Of: Carbohydrate polymers. Volume 153(2016)
• Page Start: 471
• Page End: 481
• Publication Date: 2016-11-20
• Subjects: Chitosan (PubChem CID: 71853) -- Polyethylene glycol (PubChem CID: 174) -- Sodium dodecyl sulfate (PubChem CID: 3423265) -- Pyridine (PubChem CID: 1049) -- N, N-dimethylformamide (PubChem CID: 6228) -- Phthalic anhydride (PubChem CID: 6811) -- Thionyl chloride (PubChem CID: 24386) -- Methanol (PubChem CID: 887) -- Poloxamer 407 (PubChem CID: 24751) -- Polyvinylpyrrolidone (PubChem CID: 6917); Nanosuspension -- Stability -- Chitosan -- Deacetyl mycoepoxydience; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2016.08.002
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: A series of Methoxypolyethylene glycol (M PEG)–grafted chitosan were designed. M PEG–grafted chitosan was first used for stable nanocrystals preparation. 90/4k of M PEG–grafted chitosan has the best effect on stability. Abstract: Here a series of multifunctional stabilizers was designed and used in a nanosuspension stability enhancement study. Methoxypolyethylene glycol (M PEG)–grafted chitosan, accompanied by space steric hindrance, an electrostatic repulsion function, and a solvation effect, is a multifunctional stabilizer. Deacetyl mycoepoxydience (DM) nanosuspension was prepared using the anti-solvent precipitation approach. The effects of the DM and the multifunctional stabilizer concentration, solvent to anti-solvent ratio, crystallization and storage temperature, and ultrasonic time on drug particle formation during the anti-solvent processing were investigated and the nanosuspension stability was studied. The nanosuspension showed dendritic-like nanostructures and a crystalline state in a morphology and crystalline state study. The optimized drug and multifunctional stabilizer concentration range were selected through the response surface optimization method. The most appropriate and stable nanosuspension could be obtained through the optimal parameters. This study demonstrated that M PEG–grafted chitosan (M PEGC) could be used as a multifunctional stabilizer to control particle size and improve nanosuspension stability.