Antioxidant and hepatoprotective activities of polysaccharides from Anoectochilus roxburghii. (20th November 2016)

• Record Type: Journal Article
• Authors: Zeng, Biyu; Su, Minghua; Chen, Qingxi; Chang, Qiang; Wang, Wei; Li, Huihua
• Is Part Of: Carbohydrate polymers. Volume 153(2016)
• Page Start: 391
• Page End: 398
• Publication Date: 2016-11-20
• Subjects: Anoectochilus roxburghii -- Polysaccharides -- Characterization -- Antioxidant and hepatoprotective activities; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2016.07.067
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Three polysaccharides (ARPPs) were isolated from Anoectochilus roxburghii . The antioxidant and hepatoprotective activities of ARPPs were investigated. ARPP80 showed high antioxidant and hepatoprotective activities. Findings showed that ARPPs have potential beneficial effects in functional foods. Abstract: The physicochemical properties (molecular weights and monosaccharide compositions), antioxidant and hepatoprotective activities of polysaccharides (ARPPs: ARPP30, ARPP60 and ARPP80) isolated from Anoectochilus roxburghii were investigated. ARPP80 exhibited relatively strong antioxidant activities in a concentration-dependent manner. In mice subjected to carbon tetrachloride-induced hepatotoxicity, ARPP80 pretreatment significantly ( p < 0.01) reduced the levels of aspartate and alanine amino transferases and malonyldialdehyde, prominently ( p < 0.01) restored the levels of superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione in serum or liver homogenate. These hepatoprotective effects were comparable to those of the standard drug silymarin at the same dose (200 mg/kg). The study clearly demonstrated that ARPPs, especially ARPP80, might be suitable as functional foods or hepatoprotective drugs.