A novel porous aspirin-loaded (GO/CTS-HA)n nanocomposite films: Synthesis and multifunction for bone tissue engineering. (20th November 2016)

• Record Type: Journal Article
• Authors: Ji, Mingxiang; Li, Han; Guo, Hailin; Xie, Anjian; Wang, Shaohua; Huang, Fangzhi; Li, Shikuo; Shen, Yuhua; He, Jiacai
• Is Part Of: Carbohydrate polymers. Volume 153(2016)
• Page Start: 124
• Page End: 132
• Publication Date: 2016-11-20
• Subjects: Graphene oxide/chitosan-hydroxyapatite -- Porous nanocomposite film -- Layer-by-layer assembly technology -- Biomimetic mineralization -- Bone tissue engineering; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2016.07.078
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: The porous GO/CTS-HA composite film is successfully synthesized via a facile method. It is prepared by combining LBL technology with biomimetic mineralization method. The film with biocompatibility provides platform for the proliferation of mMSCs. Aspirin can alleviate the pain and give a better environment for bone regeneration. Abstract: A novel porous graphene oxide (GO)/chitosan (CTS)-hydroxyapatite (HA) nanocomposite film was successfully prepared for the first time by combining layer-by-layer (LBL) assembly technology with biomimetic mineralization method. The LBL technology was used to control the thickness of film as well as induce the biomimetic mineralization of biocompatible HA. The obtained (GO/CTS-HA)n film provided ideal platform for the proliferation of mouse mesenchymal stem cells (mMSCs). The pore size in the film is about 300 nm, and the porous architecture made the film have high aspirin loading efficiency. Also the accumulated loading dosage could be adjusted by the film thickness, and the sustained release of aspirin could ensure well anti-inflammatory effect. The above advantages may alleviate the pain of patients and give the better environment for bone regeneration. This multifunctional aspirin-loaded (GO/CTS-HA)n film provided an inspiration for the synthesis of novel porous inorganic/biomacromolecule nanocomposite films as the biocoatings applied in bone tissue engineering.