Treating KRAS-mutant NSCLC: latest evidence and clinical consequences. (September 2017)

• Record Type: Journal Article
• Authors: Garrido, Pilar; Olmedo, María Eugenia; Gómez, Ana; Paz Ares, Luis; López-Ríos, Fernando; Rosa-Rosa, Juan Manuel; Palacios, José
• Is Part Of: Therapeutic advances in medical oncology. Volume 9:Number 9(2017)
• Page Start: 589
• Page End: 597
• Publication Date: 2017-09
• Subjects: genomic profiling -- KRAS -- non-small cell lung cancer -- predictive factor -- prognostic factor; Oncology -- Periodicals; Cancer -- Treatment -- Periodicals; 616.994005
• DOI: 10.1177/1758834017719829
• Languages: English
• ISSNs: 1758-8340

Abstract

KRAS mutations represent one of the most prevalent oncogenic driver mutations in non-small cell lung cancer (NSCLC). For many years we have unsuccessfully addressed KRAS mutation as a unique disease. The recent widespread use of comprehensive genomic profiling has identified different subgroups with prognostic implications. Moreover, recent data recognizing the distinct biology and therapeutic vulnerabilities of different KRAS subgroups have allowed us to explore different treatment approaches. Small molecules that selectively inhibit KRAS G12C or use of immune checkpoint inhibitors based on co-mutation status are some examples which anticipate that personalized treatment for this challenging disease is finally on the horizon.