Neuroprotective oleanane triterpenes from the roots of Bupleurum chinense. Issue 6 (15th March 2016)

• Record Type: Journal Article
• Authors: Li, Dan-Qi; Zhou, Le; Wang, Di; Wu, Jie; Li, Ling-Zhi; Huang, Xiao-Xiao; Liu, Qing-Bo; Wu, Ying-Ying; Lin, Song; Yang, Jing-Yu; Song, Shao-Jiang; Wu, Chun-Fu
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 6(2016)
• Page Start: 1594
• Page End: 1598
• Publication Date: 2016-03-15
• Subjects: Neuroprotective effects -- Cytotoxicity -- Bupleurum chinense D.C. -- Triterpenoids; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.02.004
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: The discovery of new natural compounds with pharmacological properties is an increasingly important field, and a continuous phytochemical investigation of the roots of Bupleurum chinense D.C. has led to the isolation of17 triterpenoids, including three new oleanane triterpenes (1 –3 ) together with14 known ones. Their structures were determined on the basis of 1D and 2D NMR spectra as well as HR-ESI-MS data. The cytotoxicities of all compounds against five selected human cancer cell lines were assayed. Only compounds9 and14 exhibited moderate activities. Recently, a number of investigations have focused on the neuroprotective properties of triterpenoids in B. chinense . In order to expand our knowledge about this herb, the neuroprotective effects of compounds1 –17 against hydrogen peroxide (H2 O2 )-induced neuronal cell damage in human neuroblastoma SH-SY5Y cells were evaluated. Compounds1 –3, 6 –7 showed significant neuroprotective effects against H2 O2 -induced SH-SY5Y cell death. Preliminary structure–activity relationships (SARs) between neuroprotective effects and the isolates were also discussed.