Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30. Issue 2 (15th January 2016)

• Record Type: Journal Article
• Authors: Zhou, Xuefeng; Fang, Wei; Tan, Suiyi; Lin, Xiuping; Xun, Tianrong; Yang, Bingjie; Liu, Shuwen; Liu, Yonghong
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 2(2016)
• Page Start: 361
• Page End: 365
• Publication Date: 2016-01-15
• Subjects: Aspergillus niger -- Aspernigrins -- Malformin C -- HIV-1 SF162; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.12.005
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Two new 2-benzylpyridin-4-one containing metabolites, aspernigrins C (3 ) and D (4 ), together with six known compounds (1, 2, and5 –8 ), were isolated from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30. The structures of the new compounds were determined by NMR, MS, and optical rotation analyses. All the isolated compounds were evaluated for their inhibitory activities against infection with HIV-1 SF162 in TZM-bl cells. Malformin C (5 ) showed the strongest anti-HIV-1 activity with IC50 of 1.4 ± 0.06 μM (selectivity index, 11.4), meanwhile aspernigrin C (3 ) also exhibited potent activity with IC50 of 4.7 ± 0.4 μM (selectivity index, 7.5).