Novel skeleton compound Allomyrinanoid A and two purine alkaloids from the adult of Allomyrina dichotoma L. Issue 2 (15th January 2016)

• Record Type: Journal Article
• Authors: Niu, Lanlan; Gao, Jiayu; Li, Haidi; Liu, Junna; Yin, Weiping
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 2(2016)
• Page Start: 366
• Page End: 369
• Publication Date: 2016-01-15
• Subjects: Insect Allomyrina dichotoma L. -- New skeleton compound -- Allomyrinanoid A -- Adenine-9-methylaldehyde oxime B -- 6-N-Methyleneimine-adenine-9-methylaldehyde oxime B -- Natural products; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.12.012
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Three novel antibacterial compounds including one methylnorbornane-carboxylate and two purine alkaloids derivatives, named Allomyrinanoid A (1 ), adenine-9-methylaldehyde oxime B (2 ) and 6- N -methyleneamine-adenine-9-methylaldehyde oxime B (3 ), as well as another two known compounds Δ 12 -tricosednoic acid (4 ) and Uracil (5 ) were firstly identified from Allomyrina dichotoma L. Abstract: Three new compounds were isolated from the adult insect of Allomyrina dichotoma L. for the first time. A new skeleton compound is named as Allomyrinanoid A (1 ) originated from the familiar norbornane derivatives and two new compounds of purine alkaloid are named as adenine-9-methylaldehyde oxime B (2 ) and 6- N -methyleneimine-adenine-9-methylaldehyde oxime B (3 ). The compounds (2 ) and (3 ) are the tautomers of imine–enamine and creatively separated form the solvent using column chromatography method. The structures of all isolated compounds were established by spectroscopic methods including analyses of their 1D, 2D NMR and HRESI-MS data, and confirmed by comparison of the literature data. These new components displayed antibacterial activities against both Gram-positive and Gram-negative strain.