Chetracins E and F, cytotoxic epipolythiodioxopiperazines from the marine-derived fungus Acrostalagmus luteoalbus HDN13-530. Issue 1 (19th December 2017)

• Record Type: Journal Article
• Authors: Yu, Guihong; Wang, Yanjuan; Yu, Rilei; Feng, Yanyan; Wang, Lu; Che, Qian; Gu, Qianqun; Li, Dehai; Li, Jing; Zhu, Tianjiao
• Is Part Of: RSC advances. Volume 8:Issue 1(2018)
• Page Start: 53
• Page End: 58
• Publication Date: 2017-12-19
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra12063j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Three epipolythiodioxopiperazines with two new ones were isolated from a marine-derived fungus, and all of them exhibited extensive cytotoxicity. Abstract : Two new epipolythiodioxopiperazines, named chetracins E and F (1 and2 ), along with the known chetracin C (3 ), were isolated from the fungus Acrostalagmus luteoalbus HDN13-530. Their structures were elucidated based on the NMR, MS and CD data, as well as chemical conversion. All of the compounds exhibited cytotoxicity against the tested five cancer lines in low-micromolar or nanomolar IC50 values. The computational docking indicated that compounds1–3 could bind to the C-terminal of heat shock protein 90 (Hsp90), which was in line with the experimental observation of decreases in levels and active forms of Hsp90 client proteins.