Towards sustainable kinetic resolution, a combination of bio-catalysis, flow chemistry and bio-based solvents. Issue 1 (11th December 2017)

• Record Type: Journal Article
• Authors: Iemhoff, Andree; Sherwood, James; McElroy, Con R.; Hunt, Andrew J.
• Is Part Of: Green chemistry. Volume 20:Issue 1(2018)
• Page Start: 136
• Page End: 140
• Publication Date: 2017-12-11
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c7gc03177g
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : The esterification of 2-phenylpropionic acid was investigated as a model system for enzyme catalysed (CALB, Novozyme 435) reactions in bio-based solvents. Abstract : The esterification of 2-phenylpropionic acid was investigated as a model system for enzyme catalysed (CALB, Novozyme 435) reactions in bio-based solvents. A multi-parameter correlation taking into account solvent parameters was developed to explain experimental observations. A continuous flow process using p -cymene as the solvent was operated over several weeks, thus combining a sustainable solvent and flow chemistry for kinetic resolution.