Identification of the Al-binding proteins that account for aluminum neurotoxicity and transport in vivo. Issue 1 (14th December 2017)

• Record Type: Journal Article
• Authors: Cheng, Dai; Wang, Xiaomei; Xi, Yu; Cao, Jiankang; Jiang, Weibo
• Is Part Of: Toxicology research. Volume 7:Issue 1(2018:Jan.)
• Page Start: 127
• Page End: 135
• Publication Date: 2017-12-14
• Subjects: Toxicology -- Periodicals; 615.9005
• DOI: 10.1039/c7tx00261k
• Languages: English
• ISSNs: 2045-452X

Abstract

Abstract : Studies have shown that aluminum (Al) is the most abundant neurotoxic element on Earth, and is implicated in the pathogenesis of Alzheimer's disease (AD). Abstract : Studies have shown that aluminum (Al) is the most abundant neurotoxic element on Earth, and is implicated in the pathogenesis of Alzheimer's disease (AD). However, the mechanisms underlying Al-induced neurotoxicity are still largely elusive. Based on affinity analyses with Al and LC-LTQ-MS, we have found that serum albumin, brain CK-B and 14-3-3ζ protein have a high affinity for Al 3+, and albumin has a much stronger affinity for Al than transferrin. The normal activity of CK-B, and physiological combination of 14-3-3ζ with tau can be severely perturbed by Al. We anticipate that our assay will provide a new focus concerning the mechanism underlying Al-induced neurotoxicity, and aid the design of strategies to prevent AD and other human diseases related to Al overload.