Dexmedetomidine prevent postoperative nausea and vomiting on patients during general anesthesia: A PRISMA-compliant meta analysis of randomized controlled trials. Issue 1 (January 2017)

• Record Type: Journal Article
• Authors: Jin, Shenhui; Liang, Dong Dong; Chen, Chengyu; Zhang, Minyuan; Wang, Junlu
• Other Names: Barkin. Robert L. section editor.
• Is Part Of: Medicine. Volume 96:Issue 1(2016)
• Publication Date: 2017-01
• Subjects: dexmedetomidine -- meta-analysis -- nausea -- vomiting; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000005770
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Background: Postoperative nausea and vomiting (PONV) is a frequent complication in postoperative period. The aim of this article was to evaluate the effect of dexmedetomidine on PONV. Method: RevMan 5.3 software was applied for performing statistic analysis. Twenty-four trials with 2046 patients were included. Results: The PONV of the dexmedetomidine group was significantly lower compared with the placebo group (0.56, 95% CI: 0.46, 0.69). Subgroup analysis further confirmed the effect of dexmedetomidine (irrespective of administration mode) ( P < 0.00001). Perioperative fentanyl consumption in dexmedetomidine group were also reduced significantly ( P < 0.00001). Whereas, side effects such as bradycardia, hypotension increased in dexmedetomidine group (especially in loading dose mode and loading dose plus continuous infusion mode). Conclusions: Dexmedetomidine administrated in continuous infusion mode has the advantage to prevent PONV as well as reduce side effects such as bradycardia and hypotension. Abstract : Supplemental Digital Content is available in the text