Airflow limitation as a risk factor for low bone mineral density and hip fracture: The Hordaland Health Study (HUSK) – 10 years follow-up of a general population. Issue 1 (1st January 2016)

• Record Type: Journal Article
• Authors: Herland, Trine; Apalset, Ellen M; Eide, Geir Egil; Tell, Grethe S; Lehmann, Sverre
• Is Part Of: European clinical respiratory journal. Volume 3:Issue 1(2016)
• Publication Date: 2016-01-01
• Subjects: lung function -- bone mineral density -- hip fracture -- airflow limitation -- population study; Lungs -- Diseases -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Lung Diseases; Lungs -- Diseases; Respiratory organs -- Diseases; Europe; Periodicals; Electronic journals; Periodicals; 616.24
• DOI: 10.3402/ecrj.v3.32214
• Languages: English
• ISSNs: 2001-8525

Abstract

Abstract : Aim: To investigate whether airflow limitation is associated with bone mineral density (BMD) and risk of hip fractures. Methods: A community sample of 5, 100 subjects 47–48 and 71–73 years old and living in Bergen was invited. Participants filled in questionnaires and performed a post-bronchodilator spirometry measuring forced expiratory volume in 1 second (FEV1 ) and forced vital capacity (FVC). All attendants were invited to have a BMD measurement of the hip. During 10 years of follow-up, information on death was collected from the Norwegian Cause of Death Registry, and incident hip fractures were registered from regional hospital records of discharge diagnoses and surgical procedure codes. Results: The attendance rate was 69% ( n =3, 506). The prevalence of chronic obstructive pulmonary disease (COPD) (FEV1 /FVC<0.7) was 9%. In multiple logistic regression, the lowest quartile of BMD versus the three upper was significantly predicted by FEV1 /FVC<0.7 and FEV1 % predicted (odds ratio [OR]: 1.58, 95% confidence interval [CI]: 1.11 to 2.25, and OR per increase of 10%: 0.92, 95% CI: 0.86 to 0.99, respectively). Hip fracture occurred in 126 (4%) participants. In a Cox regression analysis, FEV1 % predicted was associated with a lowered risk of hip fracture (hazard ratio per increase of 10%: 0.89, 95% CI: 0.79 to 0.997). Conclusion: Airflow limitation is positively associated with low BMD and risk of hip fracture in middle-aged and elderly.