Participation in research bronchoscopy: a literature review. Issue 1 (1st January 2016)

• Record Type: Journal Article
• Authors: Martinsen, Einar Marius Hjellestad; Leiten, Elise Orvedal; Bakke, Per Sigvald; Eagan, Tomas Mikal Lind; Grønseth, Rune
• Is Part Of: European clinical respiratory journal. Volume 3:Issue 1(2016)
• Publication Date: 2016-01-01
• Subjects: COPD -- clinical research -- research subjects -- human volunteers -- motivation -- refusal to participate; Lungs -- Diseases -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Lung Diseases; Lungs -- Diseases; Respiratory organs -- Diseases; Europe; Periodicals; Electronic journals; Periodicals; 616.24
• DOI: 10.3402/ecrj.v3.29511
• Languages: English
• ISSNs: 2001-8525

Abstract

Abstract : Bronchoscopy is the preferred method for collecting biological samples from the lower airways of subjects in clinical research. However, ensuring participation in clinical research can be challenging when the research includes an invasive procedure. For this report we reviewed the literature to look for information on participation in research bronchoscopy studies to better design our own study, the Bergen COPD Microbiome study (MicroCOPD). We performed a systematic literature search on participation in research bronchoscopy studies in February 2014 using the search engines of PubMed and EMBASE. The literature search resulted in seven relevant papers. Motivation was an end point in six of the seven papers, but reasons for declining participation and recruitment strategies also seemed important. Human subjects participate in research bronchoscopy studies for personal benefit and altruistic reasons. Inconvenience associated with research, in addition to fear of procedures, is considered a barrier. Radio, especially news stations, generated the most inquiries for a clinical study involving bronchoscopy. There is a lack of information on participation in research bronchoscopy studies in the literature. A bronchoscopy study has been initiated at Haukeland University Hospital, Bergen, Norway, to examine the role of the microbiome in COPD, and participation will be explored as a substudy.