Comparison of myelin water fraction values in periventricular white matter lesions between multiple sclerosis and neuromyelitis optica spectrum disorder. (October 2016)

• Record Type: Journal Article
• Authors: Jeong, In Hye; Choi, Joon Yul; Kim, Su-Hyun; Hyun, Jae-Won; Joung, AeRan; Lee, Jongho; Kim, Ho Jin
• Is Part Of: Multiple sclerosis. Volume 22:Number 12(2016)
• Page Start: 1616
• Page End: 1620
• Publication Date: 2016-10
• Subjects: Myelin water imaging -- multiple sclerosis -- neuromyelitis optica spectrum disorder -- demyelination; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458516636247
• Languages: English
• ISSNs: 1352-4585

Abstract

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory autoimmune diseases of the central nervous system. We hypothesized that the degree of demyelination within lesions in MS and NMOSD would differ as the pathophysiology of the two diseases do. We used myelin water imaging to compare the myelin water fraction (MWF) in 106 periventricular white matter (PVWM) lesions in 27 MS patients and 51 PVWM lesions in 20 NMOSD patients. The MWF was significantly reduced in the MS compared with the NMOSD lesions, suggesting that myelin loss was more severe in MS than in NMOSD.