Machine learning detects EEG microstate alterations in patients living with temporal lobe epilepsy. (October 2018)

• Record Type: Journal Article
• Authors: V, Kiran Raj; Rajagopalan, Shyam Sundar; Bhardwaj, Sujas; Panda, Rajanikant; Reddam, Venkateswara Reddy; Ganne, Chaitanya; Kenchaiah, Raghavendra; Mundlamuri, Ravindranadh C; Kandavel, Thennarasu; Majumdar, Kaushik K; Parthasarathy, Satishchandra; Sinha, Sanjib; Bharath, Rose Dawn
• Is Part Of: Seizure. Volume 61(2018)
• Page Start: 8
• Page End: 13
• Publication Date: 2018-10
• Subjects: EEG microstates -- Epilepsy -- Machine learning -- Fishers linear discriminant analysis; Epilepsy -- Periodicals; Epilepsy -- Periodicals; Seizures -- Periodicals; Épilepsie -- Périodiques; Electronic journals; Electronic journals; 616.853
• DOI: 10.1016/j.seizure.2018.07.007
• Languages: English
• ISSNs: 1059-1311

Abstract

Highlights: EEG microstates represents dynamics of large scale brain networks. Patients with refractory epilepsy reveal alterations in EEG microstates. Machine learning techniques using microstates can predict epilepsy even when interictal discharges are absent. Abstract: Purpose: Quasi-stable electrical distribution in EEG called microstates could carry useful information on the dynamics of large scale brain networks. Using machine learning techniques we explored if abnormalities in microstates can identify patients with Temporal Lobe Epilepsy (TLE) in the absence of an interictal discharge (IED). Method: 4 Classes of microstates were computed from 2 min artefact free EEG epochs in 42 subjects (21 TLE and 21 controls). The percentage of time coverage, frequency of occurrence and duration for each of these microstates were computed and redundancy reduced using feature selection methods. Subsequently, Fishers Linear Discriminant Analysis (FLDA) and logistic regression were used for classification. Result: FLDA distinguished TLE with 76.1% accuracy (85.0% sensitivity, 66.6% specificity) considering frequency of occurrence and percentage of time coverage of microstate C as features. Conclusion: Microstate alterations are present in patients with TLE. This feature might be useful in the diagnosis of epilepsy even in the absence of an IED.