Water dynamics in silanized hydroxypropyl methylcellulose based hydrogels designed for tissue engineering. (15th December 2018)

• Record Type: Journal Article
• Authors: Buchtová, N.; D'Orlando, A.; Judeinstein, P.; Chauvet, O.; Weiss, P.; Le Bideau, J.
• Is Part Of: Carbohydrate polymers. Volume 202(2019)
• Page Start: 404
• Page End: 408
• Publication Date: 2018-12-15
• Subjects: Hydrogel -- Cellulose -- Water dynamics -- Confinement -- Interface; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2018.08.143
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Silanized hydroxypropyl methylcellulose based hydrogels were developed for cartilage and intervertebral disc tissue engineering. Herein, study of dynamics of confined water showed two different populations, identified as hydration and bulk-like water. The diffusion coefficient showed that bulk-like water diffuses over distances ∼10 μm without being affected by the hydrogel matrix. Addition of silica nanofibers leads to improved mechanical properties and enhanced diffusion coefficient. Good diffusion within hydrogels is essential for the application.